Description

Alpha-9 Theranostics is a clinical stage, radiopharmaceutical company developing imaging and therapeutic molecules for solid and hematologic malignancies. We have multiple molecules that are headed into clinic within the next few years, and a robust pipeline of additional targets for future development. Using proprietary technology and the Company’s expertise, these differentiated molecules have the potential to meaningfully extend patients’ lives with favorable safety profiles. Alpha-9 was founded by researchers from the University of British Columbia and BC Cancer, with the goal of improving the lives of patients affected by metastatic cancers.

Position Summary:

Alpha-9 is seeking a Senior Scientist, Radiochemistry to join our growing organization.  The ideal candidate will have experience developing radiolabeling, and analytical methods for targeted, peptide-based radiopharmaceuticals.  This person will be responsible for developing and delivering novel radiolabeled diagnostic and therapeutic compounds for both pre-clinical and clinical applications. 

This position requires a high degree of collaboration, multi-tasking ability, and desire to strive in a fast-paced environment.  You will have the opportunity to contribute to the build-out and set-up of new laboratory facilities, interface with external partners, and mentor more junior staff.

 Responsibilities:

• Develop radiolabeling and manufacturing methods for compounds with imaging and therapeutic applications
• Work in multidisciplinary teams to define development project goals and timelines
• Design and conduct radiochemistry experiments leading to robust radiolabeling processes and clinical formulations that meet target product profiles
• Develop quality control procedures, analytical methods, and specifications for radiopharmaceuticals/API
• Perform technology transfer of radiolabeling and analytical methods to third party CRO and CDMO partners
• Support pre-clinical development by radiolabeling compounds for in vitro and in vivo evaluation
• Troubleshoot, identify unusual results, and design experiments that establish root cause and/or enhance knowledge of the product being developed
• Write necessary SOPs, development reports, test method protocols, batch records, and regulatory documentation
• Set up and maintain automated chemistry modules and laboratory equipment
• Conduct area radiation surveys, contamination control, and radioactive waste management
• Demonstrate good safety practices and ensure radioprotection standards are upheld

Requirements

• PhD/MSc in Radiochemistry, Chemistry, Analytical Chemistry, Nuclear Engineering or equivalent knowledge or experience
• 5+ years of experience with academic and/or commercial radiopharmaceutical development and production
• Hands on experience in radiolabeling with radioisotopes used for imaging and therapeutic applications; experience with alpha emitters is a plus
• Ability to plan and execute complex scientific projects
• Understanding of regulatory requirements for development of radiopharmaceuticals
• Demonstrated ability to troubleshoot, identify unusual results and design experiments that establish root cause
• Excellent observational, organizational, data management, and documentation skills
• A team player with excellent interpersonal skills and a strong passion for the discovery of targeted therapies in a fast-paced start-up environment