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Scholar Rock
Massachusetts, United States
22 days ago
Remix Therapeutics
Cambridge, Massachusetts, United States
30+ days ago
Scholar Rock
Massachusetts, United States
22 days ago


Scholar Rock is a clinical-stage biopharmaceutical company creating a robust pipeline of therapeutics with the potential to transform the lives of patients suffering from serious diseases, including neuromuscular disorders, cancer, and fibrosis. Our proprietary platform is rooted in our structural biology insights into the activation of latent growth factor precursors and drives the discovery and development of monoclonal antibodies that locally and selectively target these signaling proteins at the cellular level.  By exploiting structural differences in the precursor, or latent forms of growth factors, Scholar Rock intends to avoid the historical dose-limiting safety challenges associated with inhibiting the mature form of growth factors for therapeutic effect.
Our first investigational product candidate, apitegromab (SRK-015), is a selective inhibitor of the activation of latent myostatin.   We announced positive 12-month top-line data from the TOPAZ trial in April 2021, demonstrating that apitegromab has the potential to improve motor function in patients with Type 2 and Type 3 spinal muscular atrophy (SMA).  We anticipate initiating a Phase 3 registrational trial by the end of 2021 and are moving steadfast towards our aim of bringing this potential first muscle-directed therapy to patients with SMA
Our second investigational product candidate, SRK-181, is a selective inhibitor of latent TGFβ1 activation being developed to overcome primary resistance to checkpoint inhibitor therapies (CPIs), such as anti-PD-1 or anti-PD-L1 antibodies. Although CPIs have transformed the cancer treatment landscape, only approximately 20% of patients respond to treatment. We believe SRK-181 has the potential to meaningfully increase the number of patients who can benefit from CPIs. We are evaluating SRK-181 in the ongoing DRAGON Phase 1 proof-of-concept trial (NCT04291079) evaluating patients with locally advanced or metastatic solid tumors. We anticipate initial clinical response and safety data from Part A (dose escalation) portion of the trial by the end of 2021.
We continue to progress our scientific platform and preclinical programs as we apply our structural insights and protein science and antibody expertise to discover antibodies with differentiated therapeutic profiles and develop high-impact medicines for patients suffering from serious diseases. 
Summary of Position:
Scholar Rock is seeking an outstanding individual to join our team in discovering and developing novel biologic therapies. The candidate will provide medical leadership in the translational strategy and execution for drug discovery efforts.  This position requires a highly motivated and enthusiastic physician with hands-on expertise in taking novel targets from preclinical to clinical and beyond.
Position Responsibilities:
  • Provide medical vision and knowledge for novel biologic therapies in preclinical stage to establish a clear path initially to IND and ultimately to regulatory approval
  • Partner closely with the Translational Sciences group. Provide medical leadership to the Research organization to identify and vet promising drug targets, assess molecules in discovery stage and identify potential clinical indications, and select and advance promising molecules into development
  • Provide translational support to the Medical Research medical directors and broader development program teams in the IND-enabling activities, clinical trial design and execution, and regulatory submissions for development-stage molecules.
  • Partnering closely with the Medical Research medical lead for given product candidate, provide medical leadership in identifying and vetting potential indication expansion opportunities
  • Provide medical leadership and input in cross-functional project team activities, including discovery, non-clinical development, regulatory affairs, business development activities, and other efforts. 


  • Physician with strong translational expertise
  • Experience in both clinical medicine and bench research is required
  • Experience in pharmaceutical industry is preferred
  • Highly organized, outcome-oriented, self-motivated performer
  • Excellent interpersonal skills, ability to develop important relationships with key stakeholders across a variety of disciplines
  • Integrity in thought and action, creativity, team-centric mindset, integrative thinking, ability to influence decision-making without dictating, exceptional communication skills, the ability to inspire, and being a “hands-on doer” who leads from the front, not a “politician or presider”
  • Ability to prioritize multiple tasks efficiently with strong time management skills.
  • Ability to perform in a dynamic and evolving environment.

Job Information

  • Job ID: 58568986
  • Location:
    Massachusetts, United States
  • Position Title: Director, Translational Medicine
  • Company Name: Scholar Rock
  • Job Function: Clinical,
    Drug Discovery
  • Job Type: Full-Time
  • Job Duration: Indefinite
  • Min Education: Ph.D.
  • Min Experience: Over 10 Years
  • Required Travel: 0-10%
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