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University of Kansas
Lawrence, KS, United States
11 days ago
University of Kansas
Lawrence, KS, United States
14 days ago
University of Kansas
Lawrence, KS, United States
30+ days ago
University of Kansas
Lawrence, KS, United States
30+ days ago
University of Kansas
Lawrence, Kansas, United States
11 days ago

Description

Position Overview

We are currently seeking a highly motivated Postdoctoral Researcher to join the Biopharmaceutical Innovation Optimization Center (BIO Center). The ideal candidate will perform independent research associated with developing assays for drugs and their metabolites to support pharmacokinetic analysis by using LC/MS or LCMS/MS, will determine in vitro eADME (protein binding, microsome stability, plasma stability, lipophilicity) properties of drugs, develop chromatographic separation methods for drugs and their degradants from formulation media, develop assays to separate and monitor both in vitro and in vivo presence of prodrugs and their parent molecules,  and execute chemical stability, physical stability and solubility studies. All duties will be performed under supervision of the Principal Investigator. The candidate must have experience with analytical chemistry, mass spectrometry, bioanalytical chemistry, HPLC/UV method development, and drug substance characterization. The candidate is responsible for developing bioanalytical methods for experimental drugs and metabolites using mass spectrometry. The candidate will also perform assay development and validation, and physical/chemical characterization of drug candidates using HPLC/UV methodology.  The candidate will serve as an expert in the specialized research areas LCMS and HPLC.

The Biopharmaceutical Innovation and Optimization Center (BIO Center) provides drug delivery, solubilization, and stabilization services to researchers. The Center is located on the KU Lawrence West District campus in McCollum Research Laboratory. The BIO Center works with researchers at the University of Kansas and with experts around the world to transform new discoveries into products for patients. A large portion of the Centers research is conducted in partnership with the KU Cancer Center (KUCC). The KUCC is one of 67 NCI- designated Comprehensive Cancer Centers in the United States.Job Description

50% Under supervision of the Principal Investigator, lead the development, design, and implementation of research plan to meet customer expectations.  Identify and solve complex research problems.  Write and review research protocols. Conduct research, working as part of a research team in scientific areas consistent with general research areas of the BIO Center and its affiliated researchers. Activities including operating skilled instrumentation per protocols and SOP’s (LCMS/MS, HPLC, Gas Chromatography), monitor output, and performs analysis of data. Conducts research, working as part of a research team and performs research related activities. Interacts with other researchers and collaborates on lab techniques, study methodology, and suggests new techniques. 

20% Oversee the completion of data analysis and completion research reports for customers. Monitor the integrity of data collection and appropriate use of protocols, Standard Operating Procedures. Troubleshoot instrumentation maintenance and general repairs. Update documentation and analytical methodology used in support of formulations.  Provide technical and/or research related support for performing a broad range of complex laboratory and/or research related tasks. Assist with training of other researchers in equipment use, study methodology, and data collection techniques. Identifies problems, recommends and implements solutions. Coordinates data collection and screening to verify data. Acquires and performs analysis of data. All duties performed under supervision of the Principal Investigator

15% Actively participate in the activities of the BIO Center including, but not limited to, participation in scientific seminars, participation in group meetings and relevant seminars, reporting progress for the benefit of reports, collaborating with Center scientists and presentation of scholarly work in appropriate local, regional, and national settings. Coordinate with others to refine or adapt methodologies to fit research requirements.

15% Conduct literature search and research activities independently in labs. Preparation of scientific manuscripts for publication and assistance in compiling data for filing patents and seminars including maintenance of detailed records of research and findings. All relevant data must be recorded in a laboratory notebook following a standard style utilized by the laboratory.Required Qualifications

  • PhD with wet laboratory experience including sample manipulation and experimental design.
  • At least 3-years experience developing assays for drugs and their metabolites for pharmacokinetic analysis and other complex biological media while using LC/MS/MS.
  • At least 3-years experience in drug development research, including analytical chemistry, mass spectrometry, bioanalytical chemistry, and HPLC Chromatography.
  • At least 3-years experience in evaluating stability and/or solubilization of experimental compounds for characterization and/or preparation of dosing solutions.
  • Ability to perform periodic maintenance and repairs on LC, LCMS and Mass Spectrometry instrumentation as demonstrated through prior work experience.
  • Additional Candidate Instruction

    A complete application includes an online application, cover letter, resume highlighting pertinent experience relative to the required and preferred qualifications and contact information for three professional references. Only complete applications will be considered.

    Application review will begin on November 29, 2021 and continue until a successful candidate is identified.  
     

    Job Information

    • Job ID: 60994642
    • Location:
      Lawrence, Kansas, United States
    • Position Title: Postdoctoral Researcher
    • Company Name: University of Kansas
    • Job Function: Academic Faculty,
      Mathematics and Statistics,
      Research,
      Science and Technology
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